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Highly Processed Acellular Dermis
A unique soft tissue implant that is ultimately
replaced by living soft tissues as blood vessels grow into
the edges of the implant. The benefits of these innovations
include quick response of the patient's internal healing system,
lower disease rate, and dramatically reduced external scar
formation and oral deformity.
AlloDerm Defined
Core technology: AlloDerm® is an acellular
dermal matrix derived from donated human skin tissue supplied
by US AATB-compliant tissue banks utilizing the standards of
the American Association of Tissue Banks (AATB) and Food and
Drug Administration's (FDA) guidelines. Since AlloDerm® is regarded
as minimally processed and not significantly changed in structure
from the natural material, the FDA has classified it as banked
human tissue.
AlloDerm® begins with natural tissue
Human skin consists of both epidermis and
dermis. In nature, thedermis contains a framework of biochemical
and structural components that allow it to regenerate and replace
itself continually throughout life. This complex natural framework
consists of a three-dimensional arrangement of:
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Proteins with a structurally intact basement membrane
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Intact collagen fibers and bundles to support tissue ingrowth
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Intact elastin filaments for biomechanical integrity
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Hyaluronan and proteoglycans
How is AlloDerm® modified from
natural tissue?
When AlloDerm® is prepared, the human donor
tissue undergoes a multi-step proprietary process that removes
both the epidermis and the cells that can lead to tissue rejection
and graft failure, without damaging the matrix.
Once the dermal tissue has been decellularized,
the final step is preservation. The processed tissue matrix
is preserved with a patented freeze-drying process that prevents
damaging ice crystals from forming.
What components are left after this
process?
The cells responsible for immune response
and graft rejection are removed. What remains is a matrix or
framework of the natural biological components, ready to enable
the body to mount its own tissue regeneration process. |
BoneSource® Classic – Hydroxyapatite
Cement-Polymer-calcium Phosphate Composites – an Injectable
Bone Substitute
This material is Hydroxyapatite cement, which
can be likened to a plaster of paris compound, and is used
as a foundation for bone regeneration, facilitating previously
impossible cranio-facial repairs and reconstruction. BoneSource® Classic is an osteoconductive, isothermic bone substitute (cement)
made from calcium phosphate salts and sodium phosphate solution.
BoneSource® Classic offers excellent biocompatibility and
high mechanical stability while being easy to handle in the
operating room.
Unique Features and Benefits:
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An ideal bone graft substitute for non-stress-bearing
applications in skeletal tissues, such as filling cranial
defects.
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Quick - saves valuable time in the OR by providing powder
pre-packaged in a conventient mixing bowl.
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Easy - eliminates potential variability and simplifies
mixing by providing a set amount of sodium phosphate solution
that is completely injected into the powder.
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Proven - clinically proven with more than ten years of
supportive literature
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Self-setting cement
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Forms putty-like substance when mixed with sodium phosphate
solution that can be easily shaped and applied.
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Forms a structurally stable implant after 5-10 minutes.
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Converts to hydroxyapatite within 4-6 hours.
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Excellent biocompatibility
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Maintains shape and volume over time
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Remodels to bone over time
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Isothermic - no damaging heat release to surrounding tissue
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Available in five sizes: 2.5g (1.5cc);
5g (3cc); 10g (6cc); 25g (15cc); 50g (30cc)
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